Available
PT-141
- Synthetic research peptide for in-vitro structure & function studies
- Independently HPLC-tested and batch-verified
- Batch-specific Certificate of Analysis included with every order
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Every vial is quality-checked to ensure purity and batch-to-batch consistency.
Verified lab quality
- HPLC-tested to ≥ 98% (HPLC) purity
- Batch-specific Certificate of Analysis
- Stored under controlled laboratory conditions
Research Use Only. Not for human or veterinary use. By purchasing you confirm you are a qualified researcher and accept responsibility for safe, lawful handling.
Introduction
The PT-141 peptide has gained continued scientific attention due to its unique mode of action among melanocortin receptor studies. While numerous peptides under scientific study concentrate on endocrinological signaling and tissue function, PT-141 is investigated for its effects on central melanocortin receptors and is useful in neurobiological and receptor-based laboratory research.
In the UK, research laboratories, analysis facilities, and research institutions keep investigating the actions of various ligands in the melanocortin receptor system in order to develop greater insight into complicated physiological signaling systems. With advancing scientific knowledge, scientists require well-characterized materials with documented analysis and manufacturing information.
PT-141 is provided for research purposes only for educational and laboratory use. It is designed solely for scientific investigation and research. It is not provided for therapeutic use, nor as a drug or veterinary medication.
PT-141
Also referred to as Bremelanotide in the scientific literature, PT-141 is a synthetic peptide generated as a result of structural manipulation of naturally-occurring melanocortin-derived peptides. The changes in the structure of PT-141 were performed to achieve increased molecular stability while maintaining its affinity to some particular subtypes of melanocortin receptors.
In laboratory settings, PT-141 is used in receptor pharmacology research aimed at studying intracellular signalling processes, interactions between the ligand and the receptor and cellular response to these events. One of the focuses of the study is the role played by melanocortin receptor activation in intracellular communication and chemical regulation.
The relatively short amino acid chain of PT-141 makes it a subject of analytical chemistry research, such as identification and stability studies.
In peptide science, selectivity of the receptors is one of the most topical issues; therefore, PT-141 is widely used for comparative studies with other melanocortin peptides.
How It Is Studied
Scientific experiments using PT-141 tend to be conducted in laboratory models rather than being applied in clinical settings. The scientific design often seeks to enhance knowledge of receptor biology and not to measure the therapeutic effectiveness.
Currently, areas of laboratory experimentation include:
- Binding properties of melanocortin receptors
- Signaling pathways post receptor activation
- Comparative analysis of peptide-receptor binding affinities
- Structure activity relationship
- Signaling pathway within cells
- Models of neuroendocrine signaling
- Peptide stability during analysis
Scientists can incorporate receptor assays and biochemical analysis as well as modeling and computational simulation techniques in order to gain more insight into the effect that structure modifications have on receptor recognition.
State-of-the-art analytical laboratories explore degradation routes, peptide stability in storage conditions and effect of environment on molecular stability. These investigations provide useful information on peptide chemistry and analytical methods.
Scientific Characteristics
In terms of the biochemical properties, PT-141 can be considered an interesting case of peptide design through rational peptide engineering. The structural changes affect the interaction with receptors and provide increased stability against naturally existing peptides.
There are several factors that make it a valuable scientific tool for further research:
Receptor Selectivity
The studies of affinity among various subtypes of melanocortin receptors give the scientists an insight into receptor-specific pathways of signal transduction.
Molecular Stability
Synthesis is optimized for higher stability to enzymatic digestion under controlled laboratory conditions, providing reliable analysis.
Analytical Compatibility
The compound can be investigated using such conventional laboratory methods as reversed-phase chromatography and mass spectrometry, which makes it possible to perform quality control.
Structure-Activity Research
The comparison of related peptide analogues gives information about the influence of certain amino acid changes on receptor recognition and signaling.
All these factors make PT-141 a valuable reference peptide in research.
Current Research Areas
There is no end to scientific curiosity as researchers study the extended biological relevance of melanocortin signaling pathways.
Current laboratory studies being undertaken involve:
Receptor Pharmacology
Scientists study receptor kinetics, ligand specificity, and intracellular signaling mechanisms involved to better understand the field of melanocortin.
Peptide Chemistry
Analytical labs study the molecular structure of peptides, optimization of syntheses and characterization of peptides by means of laboratory techniques.
Neurobiological Research
Experimental models study signaling pathways that exist between melanocortin receptors and other neurological signaling pathways.
Computational Modelling
Computational molecular modeling assists in predicting receptor interaction and experimental observations made in the laboratory.
Comparative Peptide Research
Scientists make comparisons between PT-141 and other similar peptides to understand structural differences affecting receptor selectivity and biochemical properties.
In the United Kingdom, peptide studies incorporate computer-aided modeling, analytical chemistry, and molecular biology in order to create a deeper understanding of peptide-receptor interactions.
Research Quality & Testing
Scientific study can only be performed on high-quality material with reliable analytical documentation provided for this material.
Most of the quality-oriented laboratories check the identity of peptides using various analytical methods combined together.
Independent HPLC Testing
One of the most widely-used methods is the High-performance Liquid Chromatography (HPLC). This method allows checking the chromatographic purity of the peptide and revealing any impurities that may be present in the sample of research material.
LC-MS Verification
In addition to this, LC-MS method can be used to separate peptides from one another and to define their molecular masses.
Batch-Specific Certificate of Analysis
All of the batches of peptides should be supplied with a batch COA containing the following analytical data:
- Molecular identity of the peptide
- Chromatographic data
- Batch traceability data
This is required to meet laboratory documentation requirements and make your research repeatable.
Research Documentation
This documentation may include the following data:
- ID of the manufacturing batch
- Summary of analytical testing
- Verification of purity of the peptide
- Recommendations on storage and handling
All of these methods allow performing reproducible research at a laboratory and meeting scientific standards accepted in UK.
Laboratory Storage
Correct storage is significant in ensuring that the peptides maintain their integrity before they are analyzed.
Issues related to general laboratory practices are as follows:
- Storage based on recommended guidelines provided by the manufacturers.
- Storage should be done in such a way that they are not exposed to excess moisture and light.
- Appropriate laboratory environment during the process of storage.
- Minimizing handling in order to avoid any form of contamination.
- Tracing through recording of batch numbers during the course of the experiment.
- Correct preparation for analysis as per laboratory protocol.
Conclusion
PT-141 is still one of the key fields of study in the context of melancortin receptors because of its unique biochemical properties and potential for further studies in the field of receptor pharmacology. Research that is currently being conducted helps to improve knowledge about peptide-receptor interaction and intracellular signalling, as well as the peptide behaviour in a lab environment.
In the case of those who want to have high-quality material from the UK peptide provider, the analytical clarity becomes very important. It includes such aspects as the independent HPLC analysis, LC-MS validation, Certificates of Analysis for each individual batch of the product, quality control and comprehensive research documentation.
When it comes to advanced peptide science, the high-quality research material with clear analytical results becomes crucial.
Frequently asked questions
No. The information mentioned above applies only for Research Use Only materials used solely for scientific study and analysis in the laboratory environment.
The use of independent HPLC analysis makes it possible to assess chromatographic purity of the product in order to check consistency of the sample prior to starting the experiment.
A Certificate of Analysis of each batch usually includes analysis data, purity evaluation, batch information, analytical methods used and quality control data accompanying them.
LC-MS can be used for confirmation of molecular identity while HPLC serves for chromatographic purity assessment. Both techniques are used in peptide characterization studies.
Good analytical data, manufacturing history, quality control measures and reliable analytical techniques contribute to trustworthiness of research materials used in laboratory experiments.
Traceability by batches allows scientists to correlate their results with particular manufacturing data.
Technical specifications
The PT-141 research peptide is for use in the laboratory environment under controlled scientific study conditions. Prior to using this product in experiments, researchers must carefully check both the product label and the relevant batch documents.
| Chemical name | PT-141 |
| CAS number | 189691-06-3 |
| Molecular formula | C50H68N14O10 |
| Molecular weight | 1025.16 g/mo |
| Purity | ≥ 98% (HPLC) |
| Form | Lyophilised powder |
| Storage | 2°C to 8°C (refrigerated), protect from light |
All specifications, including purity values and analytical test results, should be checked against the Certificate of Analysis for the specific batch supplied.
Certificate of Analysis
Every batch of PT-141 is independently analysed by HPLC, with mass-spec for identity. A batch-specific Certificate of Analysis is supplied with your order, confirming the exact purity of the vial you receive.
Download PT-141 CoA (PDF)